20q探針

 廣州健侖生物科技?有限公司 

本司長(zhǎng)期供應(yīng)尼古丁（可替寧）檢測(cè)試劑盒，其主要品牌包括美國(guó)NovaBios、廣州健侖、廣州創(chuàng)侖等進(jìn)口產(chǎn)品，國(guó)產(chǎn)產(chǎn)品，試劑盒的實(shí)驗(yàn)方法是膠體金方法。

我司還有很多熒光原位雜交系列檢測(cè)試劑盒以及各種FISH基因探針和染色體探針等，。

20q探針

     20q出現(xiàn)缺失見于骨髓增殖性疾病（MPD）/骨髓異常增生綜合征（MDS）（4%）/急性粒細(xì)胞白血病（AML）（1%）等疾病中；其中20q12微小區(qū)域缺失見于MPD和MDS中。-20/20q-的患者預(yù)后較好，可用于指導(dǎo)臨床進(jìn)行預(yù)后判斷和治療方案的選擇，如可采用促進(jìn)造血、誘導(dǎo)分化和生物反應(yīng)調(diào)節(jié)劑等方式進(jìn)行治療。

本試劑盒主要用于白血病的20q的檢測(cè)，里面包括即用型雜交液和DAPI復(fù)染劑。

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以下是我司出售的部分FISH產(chǎn)品：

二維碼掃一掃

【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 

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【騰訊 】
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-3室

【企業(yè)文化宣傳】

Let a lot of old are with nasopharyngeal carcinoma. 40% of the world's nasopharyngeal cancer cases occur in China, especially in Guangdong and other provinces in the Southern China region. Therefore, nasopharyngeal carcinoma is called "Guangdong tumor".

Ma Jun introduced that about 70% of nasopharyngeal carcinoma patients were already in the late part of the local area when they visited the doctor. "Nasopharyngeal carcinoma metastasis is still limited to the neck, and no distant metastasis has occurred. It has not run to the liver, lung and other organs." At present, this type of patients still has 20-30% in the treatment of distant metastasis, "walk on the disease does not return", the main reason for the failure of the treatment. The accuracy of the distant metastasis is only about 57% by the traditional N staging method. Moreover, patients with similar staging often have different survival outcomes after receiving the same treatment. There is lack of effective markers in clinical practice to guide the selection of treatment options for nasopharyngeal carcinoma patients.

In recent years, with the development of molecular biology, many molecular biological indicators have been included in the evaluation system of tumor prognosis. Is there a group of gene expression changes that can predict metastasis risk of nasopharyngeal carcinoma?

To this end, Professor Ma Jun has carried out the research on the largest molecular marker of nasopharyngeal carcinoma in the world. Team doctor Tang Xinran introduced, compared and analyzed of nasopharyngeal carcinoma gene expression level, from tens of thousands of genes initially identified 137 differentially expressed genes, with statistical method from 410 patients screened 13 genes associated with distant metastasis, construction of molecular tags, the patients were divided into high risk group and the low risk group forecast. The results showed that the 5 year distant metastasis rate was 37% in the high risk group and only 9% in the low risk group.

這項(xiàng)研究由美國(guó)、加拿大、德國(guó)、瑞典等國(guó)的研究人員聯(lián)合展開，他們對(duì)現(xiàn)存和已滅絕的象類的１４個(gè)基因組進(jìn)行了測(cè)序，其中已滅絕的有美洲乳齒象、古棱齒象、哥倫比亞猛犸象和真猛犸象，現(xiàn)存的有亞洲象、非洲森林象和非洲草原象。

　　這項(xiàng)２６日發(fā)表在美國(guó)《國(guó)家科學(xué)院學(xué)報(bào)》上的研究顯示，古棱齒象混合了古非洲象、真猛犸象和非洲森林象的基因。

　　此外，哥倫比亞猛犸象和真猛犸象之間也有雜交現(xiàn)象，盡管兩者體型和棲息地不同。研究人員推測(cè)，在當(dāng)時(shí)覆蓋大陸大部分地區(qū)的冰川與北美洲溫帶地區(qū)交匯的地方，真猛犸象與哥倫比亞猛犸象相遇。

　　研究報(bào)告作者之一、加拿大麥克馬斯特大學(xué)進(jìn)化遺傳學(xué)家亨德里克·波伊納說：“基因組數(shù)據(jù)表明，大象的進(jìn)化并非以有組織的、線性的方式展開。”

　　在現(xiàn)存的大象中，關(guān)于非洲森林象和非洲草原象是否是兩種不同的物種，學(xué)術(shù)界一直存在爭(zhēng)議。新研究發(fā)現(xiàn)，非洲森林象和非洲草原象不存在雜交的基因證據(jù)，盡管兩者的棲息地相鄰，但它們?cè)谶^去５０萬(wàn)年中近乎*隔絕繁衍。

　　研究人員表示，未來(lái)將繼續(xù)研究新基因的引入是否有利于大象適應(yīng)新棲息地和波動(dòng)變化的氣候。

There are many factors in the pathogenesis of nasopharyngeal carcinoma. For many years, clinical and experimental studies have shown that the following factors are closely related to the occurrence of nasopharyngeal carcinoma.
1. genetic factors
(1) familial aggregation of many nasopharyngeal cancer patients have a family history of cancer. Nasopharyngeal carcinoma has a vertical and horizontal familial tendency.
(2) race susceptibility of nasopharyngeal carcinoma mainly in yellow, rare in Caucasians; high incidence of people emigrated (or overseas Chinese), their descendants still have a higher incidence of.
(3) regional concentrated nasopharyngeal carcinoma mainly occurs in five provinces of South China, namely Guangdong, Guangxi, Hunan, Fujian and Jiangxi, accounting for the first place in the head and neck cancer. South East Asian countries are also high - incidence areas.
(4) susceptibility genes in recent years, molecular genetics study found that nasopharyngeal carcinoma cell chromosome changes were 1, 3, 11, 12 and 17 chromosomes in nasopharyngeal carcinoma cells were found in many areas of chromosomal loss of heterozygosity (1P, 9p, 9q, 11q, 13q, 14q and 16q) may there is variation in multiple tumor suppressor genes suggest the occurrence and development of nasopharyngeal carcinoma.
2. virus infection
In 1964, Epstein and Barr first established a lymphoblastoid cell strain that could be passed from the biopsy tissue of African children's lymphoma (Burkitt lymphoma). Herpes virus particles were observed under electron microscope. Because it has different characteristics from other members of the herpes virus family, it is named Epstein-Barr virus, that is, EB virus.
The virus like lymphoblastoid cells can be isolated from the nasopharyngeal carcinoma tissue, and a few of the virus particles are visible under the electron microscope. Immunological and biochemical studies have confirmed that EB virus is closely related to nasopharyngeal carcinoma. The dynamic changes and monitoring of the titer of EB virus antibody can be used as an indicator of clinical diagnosis, prognosis and follow-up monitoring.
In addition to the EB virus, other viruses, such as coronavirus, are also considered to be involved in the development of nasopharyngeal carcinoma.
3. environmental factors
There are reports that the mortality rate of nasopharyngeal cancer in Chinese people migrating abroad has gradually decreased with the genetic algebra.  On the other hand, the white people born in Southeast Asia have increased the risk of nasopharyngeal cancer. It is suggested that environmental factors may play an important role in the pathogenesis of nasopharyngeal carcinoma.
The epidemiological survey found that the infants in the high incidence area of nasopharyngeal carcinoma in Guangdong province have salted fish in the first contact food after weaning. In addition, Guangdong cured and dried fish, also about the incidence of nasopharyngeal carcinoma. Nitrosamine precursors are all nitrite during the pickling process of these foods. When the pH value of the human gastric juice is 1~3, nitrite or nitrate, which is reduced to nitrite by cells, can be used to synthesize nitrosamines with secondary amines in the cells. These substances have a strong carcinogenic effect.
Some trace elements such as nickel, such as nickel, can also induce nasopharyngeal carcinoma.