乙型流感病毒IgG ELISA免疫診斷試劑盒

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乙型流感病毒IgG ELISA免疫診斷試劑盒

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

肥胖是一個世界性的流行病，并以驚人的速率導(dǎo)致糖尿病和心血管疾病，但目前還缺乏有效的藥物來治療肥胖。在Cell雜志上發(fā)表的兩項不相關(guān)的研究，揭示了免疫途徑在活化好的類型的脂肪(被稱為棕色和米色脂肪)中有重要作用，此類脂肪燃燒儲存的熱量，減輕體重，改善代謝健康。這一發(fā)現(xiàn)可能為肥胖及相關(guān)代謝性疾病的治療鋪平道路。
Dana-Farber癌癥研究所和哈佛醫(yī)學(xué)院Bruce Spiegelman表示：我們的想法是代謝健康可以通過激活脂肪中免疫細胞得到改善，這項研究揭示了一個令人興奮的新一類的潛在治療方法，可能有一天可用于肥胖癥相關(guān)疾病。
人類嬰兒有大量能產(chǎn)生熱量的棕色脂肪，以保護他們免受嚴寒，科學(xué)家zui近發(fā)現(xiàn)，成人體內(nèi)保留少量的棕色脂肪，寒冷暴露下或運動可激活棕色或米色脂肪，燃燒儲存的熱量，保護哺乳動物的體溫。盡管這類脂肪有用于治療這些疾病的潛力，但相對很少有人知道有關(guān)觸發(fā)這些良好類型脂肪形成的分子途徑。
在新的研究中，為了解決這個問題，Dana-Farber癌癥研究所和哈佛醫(yī)學(xué)院Spiegelman和Rajesh Rao集中在一個叫做PGC-1alpha4的蛋白(zui近發(fā)現(xiàn)的蛋白，其響應(yīng)抗阻練習(xí)促進肌肉生長)。他們發(fā)現(xiàn)，PGC-1alpha4刺激一種新發(fā)現(xiàn)的激素Metrnl的分泌，Metrnl被釋放到血液中，并在小鼠運動后的肌肉組織和寒冷暴露后的脂肪組織中產(chǎn)生。

Obesity is a worldwide pandemic and causes diabetes and cardiovascular disease at an alarming rate, but there is a lack of effective drugs to treat obesity. Two unrelated studies published in the journal Cell revealed that the immune pathways play an important role in activated types of fats known as brown and beige fats, which burn stored heat, lose weight, improve Metabolic health. This finding may pave the way for the treatment of obesity and related metabolic diseases.
Bruce Spiegelman, MD, of the Dana-Farber Cancer Institute and Harvard Medical School, said: "Our idea is that metabolic health can be improved by activating immune cells in the fat. This study reveals an exciting new class of potential treatments that may have One day can be used for obesity-related diseases.
Human babies have large amounts of calorie-producing brown fat to protect them from the cold. Researchers have recently discovered that small amounts of brown fat are retained in adults, brown or beige fat is activated or exposed in cold climates, burning stored heat and protecting mammals The body temperature. Although such fats have potential for the treatment of these diseases, relatively few people know the molecular pathways involved in triggering these good types of adipogenesis.
In a new study, Dana-Farber Cancer Institute and Harvard Medical School Spiegelman and Rajesh Rao focused on a protein called PGC-1alpha4 (a recently discovered protein that responds to anti-stress exercises to promote muscle growth) in order to address this issue. They found that PGC-1alpha4 stimulates the secretion of a newly discovered hormone known as Metrnl, which is released into the blood stream and is produced in muscle tissue in mice after exercise and in fatty tissue after cold exposure.